bibo:abstract
  • Objectives: Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficits. Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng), in oriental medicine, has been used to treat various musculoskeletal disorders. Methods: In the present study, the effects of aqueous extract of Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng) on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), inducible nitric oxide synthase(iNOS), and tumor necrosis factor-α(TNF-α) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot analysis for COX-2 iNOS, and TNF-α, and Immunofluorescence test for neurofilament were performed. Results: In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2, iNOS and TNF-α expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury, In contrast, treatment with Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng) improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng) treatment also suppressed COX-2, iNOS, and TNF-α expressions and enhanced the neurofilament expression in sciatic crushed nerve injury. Conclusions: In the present study, we have shown that Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng) is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury. (rdf:langString) (ko)
nlon:biographicalNote
  • 송윤경, 가천대학교 한의과대학 한방재활의학과교실 (xsd:string)
  • 임형호, 가천대학교 한의과대학 한방재활의학과교실, omdlimhh (rdf:langString) (naver.com)
  • 장건, 가천대학교 한의과대학 한방재활의학과교실 (xsd:string)
nlon:classificationNumberOfNLK
  • 519.42105 (xsd:string)
nlon:containedIn
dc:creator
  • 송윤경 (xsd:string)
  • 임형호 (xsd:string)
  • 장건 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Effect of aqueous extract of Sukjiyanggeun-Tang(shúdìyǎngjīn-tāng) on functional recovery and expressions of inflammatory mediators after sciatic nerve crushed injury in rat (xsd:string)
bibframe:extent
  • 26 cm (xsd:string)
  • p. 33-48 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2013 (xsd:string)
nlon:itemNumberOfNLK
  • 대495ㅎ (xsd:string)
rdfs:label
  • 熟地養筋湯 추출물이 흰쥐 좌골신경 손상 후에 기능회복과 염증 매개 인자 발현에 미치는 영향 / 장건, 송윤경,임형호 (xsd:string)
dcterms:language
dc:subject
  • Axonal regeneration (xsd:string)
  • COX-2 (xsd:string)
  • Sciatic functional index (xsd:string)
  • Sciatic nerve injury (xsd:string)
  • Shúdìyǎngjīn-tāng (xsd:string)
  • Sukjiyanggeun-Tang (xsd:string)
  • TNF-α (xsd:string)
  • iNOS (xsd:string)
dcterms:title
  • 熟地養筋湯 추출물이 흰쥐 좌골신경 손상 후에 기능회복과 염증 매개 인자 발현에 미치는 영향 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 23(2) (xsd:string)