bibo:abstract
  • 12.6살 된 수컷 Shitzu의 항문주위에 형성된 결절 조직의 생검을 실시하였다. 육안적 소견상 결절은 갈색과 검은색을 나타냈으며 절단면은 흰색의 균질한 물질로 가득 차 있었으며 일부에서는 괴사소견을 관찰할 수 있었다. 광학적 현미경 상에서 종양세포들은 농축된 핵을 가지고 있으며 일부에서는 원시 종양세포들이 인접 조직을 침습하고 있는 것을 관찰할 수 있었다. 또한 면역조직 화학적 염색상에서 농축된 종양세포, 주변조적에 침습한 종양세포와 기저세포는 EGFR, HER-2/neu, MMP-9, PKC α 등에 양성반응이 나타난 것을 관찰되었다. 일반적으로 개에서의 양성 항문주위선종은 다른 종양보다 4.5배 이상 발생된다는 보고(특히 수캐)가 있으나 조직병리학적 소견과 면역화학적 염색소견상 전형적인 항문주위선 샘암종은 보기 드물게 나타나므로 향후의 종양진단과 종양연구에 도움이 될 것으로 사료된다. (rdf:langString) (ko)
  • A 12.6-year-old, male Shitzu was diagnosed with perianal adenocarcinoma. The presented mass was brown to black, 4x3x3 cm in size, and yellowish on cut section. Microscopic findings revealed that the mass composed of variable sized clusters of hepatoid cells with inconspicuous distinct. The tumor cells were polyhedral and pyknotic and exhibited high mitotic activity. Tumor cells intermingled with basaloid cells and primitive cells invaded the adjacent normal tissues. Basaloid cells exhibited positive immunoreactivity for Epidermal growth factor receptor(EGFR), human epidermal growth factor receptor(HER-2/neu), matrix metallopnateinase 9(MMP-9), and perianal adenocarcinoma, protein kinase C alpha(PKC α). Generally, tumors of the perianal gland are common and benign 4.5 times more often than carcinoma. in the dog, particularly in males. In the present report, we examined histopathological and immunohistochemical characteristics of a rare perianal adenocarcinoma in association with proteins involved tumor metastasis and adenocarcinoma development. (rdf:langString) (en)
nlon:biographicalNote
  • Dong-wei Yuan, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Hai-jie Yang, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Ho-yong Park, Insect Biotec Co., Ltd (xsd:string)
  • Hye-rim Lee, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Il-hwa Hong, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Jin-kyu Park, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Jung-youn Han, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Kyu-shik Jeong, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, jeongks (rdf:langString) (knu.ac.kr)
  • Kyung-sook Hong, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Mi-ran Ki, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Moon-jung Goo, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Ok-kyung Hwang, Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University (xsd:string)
  • Sun Hee Do, Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University (xsd:string)
  • Sung-eun Yoo, Korea Research Institute of Chemical Technology (xsd:string)
nlon:classificationNumberOfNLK
  • 470.5 (xsd:string)
nlon:containedIn
dc:creator
  • 구문정 (xsd:string)
  • 기미란 (xsd:string)
  • 도선희 (xsd:string)
  • 박진규 (xsd:string)
  • 박호용 (xsd:string)
  • 양해걸 (xsd:string)
  • 위엔, 동웨이 (xsd:string)
  • 유성은 (xsd:string)
  • 이혜림 (xsd:string)
  • 정규식 (xsd:string)
  • 한정연 (xsd:string)
  • 홍경숙 (xsd:string)
  • 홍일화 (xsd:string)
  • 황옥경 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • 개에서의 항문주위선 샘암종 (xsd:string)
bibframe:extent
  • 29 cm (xsd:string)
  • p. 279-283 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2008 (xsd:string)
nlon:itemNumberOfNLK
  • 부641ㅅ (xsd:string)
rdfs:label
  • Perianal adenocarcinoma in dog / Hai-jie Yang, Sun Hee Do,Dong-wei Yuan,Il-hwa Hong,Mi-ran Ki,Jin-kyu Park,Moon-jung Goo,Hye-rim Lee,Ok-kyung Hwang,Jung-youn Han,Kyung-sook Hong,Ho-yong Park,Sung-eun Yoo,Kyu-shik Jeong (xsd:string)
dcterms:language
dc:subject
  • Epidermal growth factor receptor (xsd:string)
  • Human epidermal growth factor receptor (xsd:string)
  • Matrix metallopnateinase 9 (xsd:string)
  • Metastasis (xsd:string)
  • Perianal adenocarcinoma (xsd:string)
  • Protein kinase C alpha (xsd:string)
  • (xsd:string)
  • 양성 항문주위선종 (xsd:string)
dcterms:title
  • Perianal adenocarcinoma in dog (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 18(2) (xsd:string)