bibo:abstract
  • In this study to evaluate the involvement of EGFR, HER-2/neu and ALCAM(CD166) oncogene products in canine mammary neoplastic lesions, sections of archived paraffin-embedded samples of 49 mammary tumors were analyzed immunohistochemically using antibodies against human EGFR and HER-2/neu and ALCAM. These 49 tumors were divided into 2 groups: 22 benign(19 adenoma, 3 benign mixed tumors) and 27 malignant tumors(2 simple adenocarcinomas, 5 complex adenocarcinomas, 3 solid carcinoma, 5 sclerosing carcinoma, 8 malignant mixed tumors and 4 malignant myoepithelioma). As a result of immunostaining, 31.8%(7/22) of the benign tumors and 29.6%(8/27) of the malignant tumors expressed the HER-2/neu oncogene product, EGFR expression was detected in 27.3%(6/22) of benign tumors and in 22.2%(6/27) of the malignant tumors. ALCAM expression was detected in 40.9%(9/22) of benign tumors and in 7.4%(2/27) of the malignant tumors. These results suggest that some of the biological and morphological characteristics of the tumor are associated with canine mammary gland tumors, as also reported for human breast cancer, the possibility of using anti-HER-2/neu antibodies in the treatment of canine mammary tumors. (rdf:langString) (en)
  • 개에서의 유선 종양진단은 총 49 case 중에서 Human epidermal growth factor receptor(HER-2/neu, c-erbB-2), Epidermal growth factor receptor(EGFR), Activated leukocyte cell adhesion molecule(ALCAM) 등 면역조직화학적염색법을 실시하였다. 우선 49 case를 두 그룹으로 즉: 양성종양그룹(22 case)과 악성종양그룹(27 case)으로 구분하였다. 면역조직화학적 염색법의 분석 결과 HER-2/neu의 발현은 양성종양에서는 31.8%(7/22),악성종양에서는 29.6%(8/27)의 발현율을 보였고, EGFR의 발현은 양성종양에서는 27.3%(6/22), 악성종양에서는 22.2%(6/27)의 발현율을 보였으며, ALCAM의 발현은 양성종양에서는 40.9%(9/22), 악성종양에서는 7.4%(2/27)의 발현율을 보였다. 결론적으로 개에서의 유선종양진단의 발현율은 사람에서 보고된 것(25%~30%)과 비슷하게 나타났으며 임상진단분야에서 HER-2/neu 항체로 개에서의 유선종양진단에서 유용한 평가수단으로 적용될 수 있으리라 사료된다. (rdf:langString) (ko)
nlon:biographicalNote
  • Dong-wei Yuan, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Hai-jie Yang, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Ho-yong Park, Insect Biotec Co., Ltd (xsd:string)
  • Hye-rim Lee, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Il-hwa Hong, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Jin-kyu Park, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Jung-youn Han, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Kyu-shik Jeong, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy, jeongks (rdf:langString) (knu.ac.kr)
  • Kyung-sook Hong, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Mi-ran Ki, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Moon-jung Goo, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Ok-kyung Hwang, Department of Veterinary Pathology, Collage of Veterinary Medicine, Kyungpook National Univeristy (xsd:string)
  • Sun Hee Do, Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University (xsd:string)
  • Sung-eun Yoo, KOREA Research Institute of Chemical Technology (xsd:string)
nlon:classificationNumberOfNLK
  • 470.5 (xsd:string)
nlon:containedIn
dc:creator
  • 구문정 (xsd:string)
  • 기미란 (xsd:string)
  • 도선희 (xsd:string)
  • 박진규 (xsd:string)
  • 박호용 (xsd:string)
  • 양해걸 (xsd:string)
  • 위엔, 동웨이 (xsd:string)
  • 유성은 (xsd:string)
  • 이혜림 (xsd:string)
  • 정규식 (xsd:string)
  • 한정연 (xsd:string)
  • 홍경숙 (xsd:string)
  • 홍일화 (xsd:string)
  • 황옥경 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • HER-2/neu 단백질이 개 유방암에서의 발현분석 (xsd:string)
bibframe:extent
  • 29 cm (xsd:string)
  • p. 16-22 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2008 (xsd:string)
nlon:itemNumberOfNLK
  • 부641ㅅ (xsd:string)
rdfs:label
  • HER-2/neu protein expression in canine mammary adenocarcinoma / Hai-jie Yang, Sun Hee Do,Dong-wei Yuan,Il-hwa Hong,Mi-ran Ki,Jin-kyu Park,Moon-jung Goo,Hye-rim Lee,Kyung-sook Hong,Ok-kyung Hwang,Jung-youn HanHo-yong Park,Sung-eun Yoo,Kyu-shik Jeong (xsd:string)
dcterms:language
dc:subject
  • ALCAM (xsd:string)
  • Activated leukocyte cell adhesion molecule (xsd:string)
  • Adenocarcinoma (xsd:string)
  • Canine (xsd:string)
  • EGFR (xsd:string)
  • Epidermal growth factor receptor (xsd:string)
  • HER-2/neu (xsd:string)
  • Human epidermal growth factor receptor (xsd:string)
  • Mammary (xsd:string)
  • 개 유방암 (xsd:string)
  • 면역조직화학적염색법 (xsd:string)
dcterms:title
  • HER-2/neu protein expression in canine mammary adenocarcinoma (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 18(1) (xsd:string)