bibo:abstract
  • To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria male rats were treated with enrofloxacin of 50 ㎎ to 500 ㎎/㎏ b.w.. The microscopical observations of kidney and urine sediment were earned out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical Endings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease dehydration and hyperoxaluria conditions. (rdf:langString) (en)
nlon:biographicalNote
  • 오규실, 경북대학교 수의과대학 (xsd:string)
  • 오원석, 경북대학교 수의과대학 (xsd:string)
  • 이차수, 경북대학교 수의과대학 (xsd:string)
  • 정규식, 경북대학교 수의과대학, jeongks (rdf:langString) (knu.ac.kr)
  • 정다히, 경북대학교 수의과대학 (xsd:string)
  • 정원일, 경북대학교 수의과대학 (xsd:string)
  • 정재용, 경북대학교 수의과대학 (xsd:string)
nlon:classificationNumberOfNLK
  • 528.05 (xsd:string)
nlon:containedIn
dc:creator
  • 오규실 (xsd:string)
  • 오원석 (xsd:string)
  • 이차수 (xsd:string)
  • 정규식 (xsd:string)
  • 정다히 (xsd:string)
  • 정원일 (xsd:string)
  • 정재용 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Histopathological observations on the renal injury in rats administered with enrofloxacin and oxalate (xsd:string)
bibframe:extent
  • 29 cm (xsd:string)
  • p. 449-457 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2003 (xsd:string)
nlon:itemNumberOfNLK
  • 한591 (xsd:string)
rdfs:label
  • Oxalate와 enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰 / 오원석, 이차수,오규실,정원일,정재용,정다히,정규식 (xsd:string)
dcterms:language
dc:subject
  • Enrofloxacin (xsd:string)
  • Histopathology (xsd:string)
  • Kidney (xsd:string)
  • Oxalate (xsd:string)
  • Rat (xsd:string)
  • 랫트신장 (xsd:string)
dcterms:title
  • Oxalate와 enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 20(4) (xsd:string)