bibo:abstract
  • We have studied, by a nonisotopic in situ DNA end-labeling (ISEL) technique, frequency of apoptosis in the external granular layer (EGL) of the cerebellum after whole-body irradiation of newborn mice and intestinal crypt cell of adult mice by gamma-rays from <TEX>$${ }^{60}$$</TEX>Co. The extent of changes following 2 Gy(10.9 Gy/min) was studied at 2, 4, 6, 8, 12, or 24h after exposure. The maximal frequency was found 4-8h after exposure. The mice that received 0.18, 0.36, 0.54, 1.08, 1.98, or 3.96 Gy were examined 6h after irradiation. Measurements performed after irradiation showed a dose-related increase in apoptotic cells in each of the mice studied. The dose-response curves were analyzed by a linear-quadratic model; frequency(%) of apoptotic cell in the newborn mice cerebellum was (13.49±1.175)D+(-1.52±0.334)D²+0.048(r²=0.981, D=dose in Gy) and frequency(number per crypt) of apoptotic cell in the intestinal crypt of adult mice was (3.857±0.420)D+(-0.535±0.120)D²+0.155(r² =0.952, D=dose in Gy). It provides the basis required for a better understanding of results which will be obtained in any further studies for biological responses of radiation using newborn and adult mice. (rdf:langString) (en)
nlon:biographicalNote
  • 김성호, 전남대학교 수의과대학 (xsd:string)
  • 양정아, 전남대학교 수의과대학 (xsd:string)
  • 오헌, 전남대학교 수의과대학 (xsd:string)
  • 이송은, 전남대학교 수의과대학 (xsd:string)
  • 정규식, 생명공학연구소 (xsd:string)
  • 현병화, 생명공학연구소 (xsd:string)
nlon:classificationNumberOfNLK
  • 528.05 (xsd:string)
nlon:containedIn
dc:creator
  • 김성호 (xsd:string)
  • 양정아 (xsd:string)
  • 오헌 (xsd:string)
  • 이송은 (xsd:string)
  • 정규식 (xsd:string)
  • 현병화 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Biological indicator on radiation exposure using apoptosis in adult and newborn mice (xsd:string)
bibframe:extent
  • 26 cm (xsd:string)
  • p. 679-685 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 1998 (xsd:string)
nlon:itemNumberOfNLK
  • 대472 (xsd:string)
rdfs:label
  • 성숙 및 신생마우스에서 아포프토시스를 이용한 방사선 피폭의 생물학적 지표 / 오헌, 이송은,양정아,정규식,현병화, 김성호 (xsd:string)
dcterms:language
dc:subject
  • Adult (xsd:string)
  • Apoptosis (xsd:string)
  • Cerebellum (xsd:string)
  • Intestine crypt (xsd:string)
  • Irradiation (xsd:string)
  • Mouse (xsd:string)
  • Newborn (xsd:string)
  • 방사선 피폭 (xsd:string)
  • 성숙 (xsd:string)
  • 신생마우스 (xsd:string)
  • 아포프토시스 (xsd:string)
dcterms:title
  • 성숙 및 신생마우스에서 아포프토시스를 이용한 방사선 피폭의 생물학적 지표 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 38(4) (xsd:string)