bibo:abstract
  • The neutralization epitopes of the outer capsid protein VP4 of a porcine rotavirus, Gottfried strain, were studied using neutralizing monocolonal antibodies(N-MAbs). Eight N-MAbs which are specific for the were used for this analysis; ⅰ)testing the serologica reactivity of each N-MAb against different G and P types of human and animal rotavirusese ⅱ)analyzing N-MAb-resistant viral escape mutants and ⅲ)performing nucleotide sequence analysis of the VP4 gene of each N-MAb-resistant viral escape mutant. From experimental results, at least four antigenic sites(Ⅰ,Ⅱ,Ⅲ, and Ⅳ) were identified. Antigenic site I recognized by N-MAbs 24B9, 23G10, and 26A2 was separated from antigenic site Ⅱ recognized by N-MAbs 30H5, 32B3, and 29B3. However, these antigenic sites were overlapped with antigenic site Ⅲrecognized by N-MAb21A1. The other antigenic site Ⅳ recognized by N-MAb 16D2 was separated from antigenic sites Ⅰ,Ⅱ, and Ⅲ. (rdf:langString) (en)
nlon:biographicalNote
  • 강신영, 충북대학교 수의과대학/동물의학연구소 (xsd:string)
  • 김원용, 중앙대학교 의과대학 (xsd:string)
  • 송윤경, 충북대학교 수의과대학/동물의학연구소 (xsd:string)
nlon:classificationNumberOfNLK
  • 528.05 (xsd:string)
nlon:containedIn
dc:creator
  • 강신영 (xsd:string)
  • 김원용 (xsd:string)
  • 송윤경 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Analysis of antigenic site on the VP4 of porcine rotavirus, Gottfried strain (xsd:string)
bibframe:extent
  • 26 cm (xsd:string)
  • p. 343-350 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2001 (xsd:string)
nlon:itemNumberOfNLK
  • 대472 (xsd:string)
rdfs:label
  • 돼지 로타바이러스(Gottfried 주)의 VP4 항원구조분석 / 송윤경, 김원용,강신영 (xsd:string)
dcterms:language
dc:subject
  • Antigenic site (xsd:string)
  • Gottfried 주 (xsd:string)
  • N-MAb resistant excape mutant (xsd:string)
  • Rotavirus (xsd:string)
  • SSCP (xsd:string)
  • VP4 (xsd:string)
  • 돼지 로타바이러스 (xsd:string)
  • 항원구조분석 (xsd:string)
dcterms:title
  • 돼지 로타바이러스(Gottfried 주)의 VP4 항원구조분석 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 41(3) (xsd:string)