bibo:abstract
  • It is well estabilished that IL-4, IL-6, IFNγ and immunoglobulin production are increased as a consequence of advancing age, and endothelial cells increase their expression of pro-inflammatory surface protein, such as ICAM-1, as a consequence of contact with inflammatory cytokines, including IL-1, TNFα or INFγ. This study was designed to define the relationship between age-associated changes of cytokines and immunoglobulin production and ICAM-1 expression in aged mice. Serum from aged mice had elevated IL-6 and immunoglobulin levels compared to mature adult controls and activation-induced production of IFNγ of splenocytes from aged mice were increased above normal adult level. By immunoperoxidase staining, ICAM-1 in hearts of normal adult mice was expressed occasionally at low levels, but in aged mice, the number of positive blood vessels for ICAM-1 were increased and also the immunoreactivity were stronger. Therefore, these finding indicate that the altered expression of ICAM-1 eith normal aging may actually be correlative to these age-related changes in cytokiness and immunoglobulin production. (rdf:langString) (en)
nlon:biographicalNote
  • 권오덕, 전북대학교 수의과대학 (xsd:string)
  • 김무강, 충남대학교 수의과대학 (xsd:string)
  • 김성호, 전남대학교 수의과대학 (xsd:string)
  • 류시윤, 충남대학교 수의과대학 (xsd:string)
  • 박배근, 충남대학교 수의과대학 (xsd:string)
  • 윤원기, 충남대학교 수의과대학 (xsd:string)
  • 정규식, 한국과학기술연구원 생명공학연구소 유전자원센터 (xsd:string)
  • 조성환, 충남대학교 수의과대학 (xsd:string)
nlon:classificationNumberOfNLK
  • 528.05 (xsd:string)
nlon:containedIn
dc:creator
  • 권오덕 (xsd:string)
  • 김무강 (xsd:string)
  • 김성호 (xsd:string)
  • 류시윤 (xsd:string)
  • 박배근 (xsd:string)
  • 윤원기 (xsd:string)
  • 정규식 (xsd:string)
  • 조성환 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Age related changes of ICAM-1 expression in the heart of mice (xsd:string)
bibframe:extent
  • 26 cm (xsd:string)
  • p. 30-36 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 1997 (xsd:string)
nlon:itemNumberOfNLK
  • 한591 (xsd:string)
rdfs:label
  • 마우스 심장에서 노화에 따른 ICAM-1 표현양상의 변화 / 류시윤, 정규식,조성환,윤원기,박배근,김무강,권오덕,김성호 (xsd:string)
dcterms:language
dc:subject
  • Aged mice (xsd:string)
  • Heart (xsd:string)
  • ICAM-1 (xsd:string)
  • 노화 (xsd:string)
  • 마우스 (xsd:string)
  • 심장 (xsd:string)
dcterms:title
  • 마우스 심장에서 노화에 따른 ICAM-1 표현양상의 변화 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 14(1) (xsd:string)