bibo:abstract
  • The frequencies of gamma-ray-induced micronuclei (MN) in cytokinesis-blocked (CB) lymphocytes at several doses were measured in three donors of three species (human, rabbit, dog). Measurements performed after irradiation showed a dose-related increases in MN frequency in each of the donors studied. When analysed by linear-quadratic model the line of best fit was : human : y = 0.1184D + 0.01867D² + 0.01, rabbit : y = 0.0387D + 0.00528D² + 0.01 (y = number of MN/CB cells and D = irradiation dose in Gy). The relative sensitivity of rabbit lymphocytes compared with human lymphocytes was estimated by best fitting linear-quadratic model based on the radiation-induced MN data over the range from 0 Gy to 4 Gy. In the case of MN frequency with 0.2, the relative sensitivities of rabbit lymphocytes was 0.39. These data indicate that the induction of MN in rabbit CB cells following irradiation was much less sensitive to the MN induction effects of gamma-irradiation than those from human. The MN assay with dog lymphocytes was very difficult and time-consumed because the dog PHA-stimulated lymphocytes yielded cultures with very low level of CB cells formation in the condition of this experiment. Our in vitro radiobiological study confirmed that the cytogenetic response obtained in blood from rabbit can be utilized for application in environmental studies. (rdf:langString) (en)
nlon:biographicalNote
  • 강빛나, 충남대학교 수의과대학 (xsd:string)
  • 김성호, 전남대학교 수의과대학 (xsd:string)
  • 김세라, 전남대학교 수의과대학 (xsd:string)
  • 김태환, 한국원자력병원 (xsd:string)
  • 김호준, 충남대학교 수의과대학 (xsd:string)
  • 류시윤, Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Chungnam National University, syryu (rdf:langString) (cuvic.cnu.ac.kr)
  • 안미영, Texas A&M University 수의과대학 (xsd:string)
  • 이해준, 전남대학교 수의과대학 (xsd:string)
  • 정규식, 병국대학교 수의과대학 (xsd:string)
nlon:classificationNumberOfNLK
  • 528.05 (xsd:string)
nlon:containedIn
dc:creator
  • 강빛나 (xsd:string)
  • 김성호 (xsd:string)
  • 김세라 (xsd:string)
  • 김태환 (xsd:string)
  • 김호준 (xsd:string)
  • 류시윤 (xsd:string)
  • 안미영 (xsd:string)
  • 이해준 (xsd:string)
  • 정규식 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • Induction of micronuclei in human, rabbit and dog lymphocytes irradiated in vitro with gamma radiation (xsd:string)
bibframe:extent
  • 26 cm (xsd:string)
  • p. 1-6 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 2002 (xsd:string)
nlon:itemNumberOfNLK
  • 대472 (xsd:string)
rdfs:label
  • 사람, 토끼 및 개 유래 말초혈액 림프구의 미소핵을 이용한 방사선 피폭의 생물학적 선량측정 / 류시윤, 강빛나,김호준,김태환,정규식,김세라,이해준,김성호,안미영 (xsd:string)
dcterms:language
dc:subject
  • Dog (xsd:string)
  • Gamma-radiation (xsd:string)
  • Human (xsd:string)
  • Lymphcyte (xsd:string)
  • Micronuclei (xsd:string)
  • Rabbbit (xsd:string)
  • (xsd:string)
  • 말초혈액 림프구 (xsd:string)
  • 미소핵 (xsd:string)
  • 방사선 피폭 (xsd:string)
  • 사람 (xsd:string)
  • 토끼 (xsd:string)
dcterms:title
  • 사람, 토끼 및 개 유래 말초혈액 림프구의 미소핵을 이용한 방사선 피폭의 생물학적 선량측정 (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 42(1) (xsd:string)