bibo:abstract
  • To investigate the effects of cyclocreatine(CCr), a substrate analogue of creatine kinase(CK), a study was performed on the model of hepatocarcinogenesis of F344 rat with treatments of diethylnitrosamine(DEN), partial hepatectomy (PH) and 2-acetylaminofluorene(2-AAF). From 2 weeks until 14 weeks after intraperitoneal injection of DEN (200㎎/㎏), group Ⅰ (N=7) was given a diet containing 0.04% 2-AAF only, group Ⅱ (N=7) was given a diet containing 0.04% 2-AAF+1% CCr, and group Ⅲ (N=7) was given a basal diet after administration of 0.85% saline instead of DEN as a control group. All rats of group Ⅰ, Ⅱ and Ⅲ were subjected to two-thirds PH at 3 weeks after DEN or saline injection and killed at 14 weeks for studying of immunoreactivity of glutathione S-transferase placental form (GST-P). In immunohistochemical study, the number (No./㎠) and area (㎟/㎠) of GST-P positive liver foci were significantly lower in the 2-AAF+CCr treated group compared to the group treated with 2-AAF only (Mann-Whitney U test at p〈0.05). We propose here that CCr supports ATP regeneration through the creatine kinase systems less efficiently than the natural substrate creatine and that CCr is active against hepatocarcinogenesis rat models with elevated levels. This result points out the unique nature of an anticancer agent that inhibits progression of the chemical-induced hepatocarcinogenesis of rat. (rdf:langString) (en)
nlon:biographicalNote
  • Byoung-Gil Mheen, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea (xsd:string)
  • Cha-Soo Lee, College of Veterinary Medicine, Kyungpook National University, Taegu, Korea (xsd:string)
  • Sang-Joon Park, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea (xsd:string)
  • Si-Yun Ryu, College of Veterinary Medicine, Chungnam National University, Taejon, Korea (xsd:string)
  • Sung-Hwan Cho, College of Veterinary Medicine, Chungnam National University, Taejon, Korea (xsd:string)
  • Young-Heun Jee, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea (xsd:string)
nlon:classificationNumberOfNLK
  • 510.7205 (xsd:string)
nlon:containedIn
dc:creator
  • Cho, Sung-Hwan (xsd:string)
  • Jee, Young-Heun (xsd:string)
  • Lee, Cha-Soo (xsd:string)
  • Mheen, Byoung-Gil (xsd:string)
  • Park, Sang-joon (xsd:string)
  • Ryu, Si-Yun (xsd:string)
  • 정규식 (xsd:string)
dcterms:creator
nlon:datePublished
  • 2021-01-30T23:37:12 (xsd:dateTime)
dcterms:description
  • F344 랫드를 이용한 화학적 중기 간장발암모델에서의 싸이클로크레아틴의 억제효능 (xsd:string)
bibframe:extent
  • 28 cm (xsd:string)
  • p. 121-126 (xsd:string)
  • 삽도 (xsd:string)
dcterms:isPartOf
nlon:issuedYear
  • 1997 (xsd:string)
nlon:itemNumberOfNLK
  • 한547ㅎ (xsd:string)
rdfs:label
  • Cyclocreatine(1-carboxymethyl-2-iminoimidazolidine) inhibits hpatocarcinogenesis in F344 rat / Byoung-Gil Mheen, Sang-Joon Park,Young-Heun Jee,Si-Yun Ryu,Sung-Hwan Cho,Cha-Soo Lee,Kyu-Shik Jeong (xsd:string)
dc:subject
  • Cyclocreatine(creatine analogue) (xsd:string)
  • Cyclocreatine1-carboxymethyl-2 (xsd:string)
  • F344 (xsd:string)
  • Glutathione S-transferase(GST-P) (xsd:string)
  • Hpatocarcinogenesis (xsd:string)
  • Iminoimidazo (xsd:string)
  • Inhibits (xsd:string)
  • Lidine (xsd:string)
  • Rat (xsd:string)
  • 간장발암모델 (xsd:string)
  • 랫드 (xsd:string)
  • 싸이클로크레아틴 (xsd:string)
  • 억제효능 (xsd:string)
  • 중기 (xsd:string)
dcterms:title
  • Cyclocreatine(1-carboxymethyl-2-iminoimidazolidine) inhibits hpatocarcinogenesis in F344 rat (xsd:string)
rdf:type
nlon:volumeOfNLK
  • 13(2) (xsd:string)