dcterms:abstract
  • A number of toxicants have been incriminated as a causing hepatic disease. Among many detrimental injury, alcohol has been noted for hepatitis, fatty liver, fibrosis, and hepatic cirrhosis. The purpose of this study was to develop animal model for hepatic fibrosis in pigs fed ethanol, and to search for a new anti-fibrogenic agent via this model. Twelve male Landrace pigs were divided into 3 groups of 4 animals each. Group 1, 2 and 3 were fed with active ceramic water only, ceramic water + liquid diet containing 15% ethanol and normal tap water+liquid diet containing 15% ethanol for 12 weeks, respectively. At week 12, all pigs were immediately sacrificed for collection each tissue and blood. Serologically, serum ALT and AST levels were significantly reversed in group 2, as compared to group 3. They were normal range in pigs of group 1. Microscopically, macrovesicular lipid droplets and moderate hepatocellular necrosis were evident in the tap water+ethanol fed group 3. However, the active ceramic water treated group 1 showed normal architecture. Moreover, in group 2, mild fatty changes and necrosis were observed in hepatocytes. Collagen fibers were increased in spaces surrounding periportal and interlobular connective tissues in the group 3 of tap water+ethanol, but collagen synthesis and its thickness of fibrotic septa connecting portal tracts were markedily reduced in the group 2 of ceramic water+ethanol. Myofibroblasts were detected mainly in the interlobular connective tissues of pig liver of group 3 treated ethanol and tap water. Few to no myofibroblasts were observed in groups 1 and 2. CYP2E1 was not or rarely detected in group 1 fed ceramic water. However, group 2 showed slightly activation of CYP2E1 in the area of pericentral vein, while CYP2E1 was significantly activated in group 3 fed tap water and ethanol. Based on the above data, we believe that we have developed a unique alcohol induced fibrosis model in pig, which will be useful in developing anti-fibrotic agents and drugs. Furthermore, the active ceramic water used in our study had an inhibitory and may be protective against ethanol induced hepatic toxicity and fibrosis (xsd:string)
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  • born digital (xsd:string)
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  • 일반이용자 (xsd:string)
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  • 이차수 (xsd:string)
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  • 정종식 (xsd:string)
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  • 2021-01-26T07:37:57 (xsd:dateTime)
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  • 15 p (xsd:string)
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  • application/pdf (xsd:string)
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  • 학술논문 (xsd:string)
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  • 국립중앙도서관 (xsd:string)
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  • http://www.kosves.re.kr (xsd:string)
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nlon:kdc
  • 528.705 (xsd:string)
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nlon:keyword
  • Alcohol, Hepatic fibrosis, Hepatic cirrhosis (xsd:string)
rdfs:label
  • Alcohol-induced hepatic fibrosis in pig (xsd:string)
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  • 전자자료(Application) (xsd:string)
nlon:newsPosition
  • p. 345-359 (xsd:string)
nlon:newsTopic
  • 알코올[alcohol] (xsd:string)
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  • 한국 (xsd:string)
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  • 2003년 12월 (xsd:string)
  • 26卷 4號(영문) (xsd:string)
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  • 국립중앙도서관 공개 (xsd:string)
dcterms:title
  • Alcohol-induced hepatic fibrosis in pig (xsd:string)
nlon:titleOfAdditionalPhysicalForm
  • Alcohol-induced hepatic fibrosis in pig (xsd:string)
nlon:titleOfHostItem
  • Korean journal of veterinary service (xsd:string)
  • 한국가축위생학회지 (xsd:string)
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  • G701:A-00109977006 (xsd:string)